C6Medline
Free Radic
Res Commun 1990;11(1-3):109-15
Studies
on the antioxidant and free radical scavenging properties
of IdB 1016 (Siliphos®) (Siliphos®) a new flavanolignan
complex.
Comoglio
A, Leonarduzzi G, Carini R, Busolin D, Basaga H, Albano E,
Tomasi A, Poli G, Morazzoni P, Magistretti MJ
Department
of Experimental Medicine and Oncology, University of Turin,
Italy.
Silybin
has been complexed in 1:1 ratio with phosphatidyl choline
to give IdB 1016 (Siliphos®) in order to increase its
bioavailability. The antioxidant and free radical scavenger
action of this new form of silybin has been evaluated. One
hour after the intragastric administration to rats of IdB
1016 (Siliphos®) IdB decreased by about 40% the lipid
peroxidation induced in microsomes by NADPH, CCl4 and cumene
hydroperoxide, probably by acting on lipid derived radicals.
Spin trapping
experiments showed, in fact, that the complexed form of silybin
was able to scavenge lipid dienyl radicals generated in the
microsomal membranes. In addition, IdB 1016 (Siliphos®)
was also found to interact with free radical intermediates
produced during the metabolic activation of carbon tetrachloride
and methylhydrazine.
These
effects indicate IdB 1016 (Siliphos®) as a potentially
protective agent against free radical-mediated toxic damage.
PMID:
2074043, UI: 91161019
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