Ref10C2
3rd International Symposium, Flavonoids in
Biology and Medicine, Singapore (1989)
Pharmacokinetics
of a New Flavonolignan Complex (IdB 1016), (Siliphos®),
Following Single and Multiple Doses in Man
N. Barzaghi,
E. Perucla, *G. Pifferi and A. Crema
Department
of Medical Pharmacology, University of Pavia, Papia, It. and
*Inverni della Beffa S.p.A., Milan, Italy
No reference
found on Medline
This study
was designed to test the oral availability of Silybin, a major
active constitiuent of the Silybum marianum extract, is markedly
enhanced when administered in the form of phosphatidylcholine
complex (Siliphos®). This study was designed to evaluate
whether the pharmacokinetic properties of (Siliphos®)
remain unchanged after multiple dose administration in healthy
volunteers.
The study
concluded that the results are not significantly modified
during repeated administration. This means it appears not
to lose efficacy during protracted usage.
Ref10C2
|
