3rd International Symposium, Flavonoids in Biology and Medicine, Singapore (1989)
N. Barzaghi, E. Perucla, *G. Pifferi and A. Crema
Department of Medical Pharmacology, University of Pavia, Papia, It. and *Inverni della Beffa S.p.A., Milan, Italy
No reference found on Medline
This study was designed to test the oral availability of Silybin, a major active constitiuent of the Silybum marianum extract, is markedly enhanced when administered in the form of phosphatidylcholine complex (Siliphos®). This study was designed to evaluate whether the pharmacokinetic properties of (Siliphos®) remain unchanged after multiple dose administration in healthy volunteers.
The study concluded that the results are not significantly modified during repeated administration. This means it appears not to lose efficacy during protracted usage.