Ref16P23
Biochemical Pharmacology, Vol. 50 No. 8, pp. 1313-1316, 1995
Scavenging
Effect of Silipide (Siliphos®), a new Silybin-phospholipid
Complex, on Ethanol-Derived Free Radicals
A. Comoglio,
A. Tomasi*, S. Malandrino**, G. Poli*** and E. Albano****
*Departments
of Experimental Medicine and Oncology and Medical Sciences,
University of Torino; ***C.N.R. Centre of Immunogenetics and
Experimental Oncology, Torino; **Indena S.p.A. Milano and
*Institut of General Pathology, University of Modena, Italy
The results
of this study indicate that (Siliphos®) effectively scavenges
hydroxhethyl radicals. However, this effect is lost when the
same amount of pure silybin is administered instead. The ability
of Silipide (Siliphos®) to scavenge ethanol-derived radicals
along with its antioxidant activity suggests that this drug
might be potentially useful in counteracting free radical-mediated
injuries involved in the development of liver damage caused
by alcohol abuse.
Ref16P23
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