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European Journal of Drug Metabolism and PharmacoKinetics, 1992,
Vol. 17, No. 1, pp.39-44
Siliphos®
versus Silybin
Comparative
bioavailability of IbD 1016 (Siliphos®), a new flavanolignan
complex, in rats
P. Morazzoni1,
M.J. Magistretti1, C. GIACHETTI2 and G. ZANOLO2
1 Inverni
della Beffa Rasearch and Development Laboratories, Milan,
Italy
2 "Antoine
Marxer" Institute for Biomedical Research, Ivrea, Italy
The results
of this study indicate a superior bioavailabilty of silybin
administered orally as IbD 1016 (Siliphos®). This was
due mainly to an impressive increase in gastrointestinal absorbtion.
It also
clearly confirmed that pure silybin has a very low bioavailability;
indeed, administered by oral route it does not result in detectable
plasma levels of either unmodified or total silybin.
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