Ref11P1 - Liver Protective Activity

Department of Biochemistry
Faculty of Medicine
National University of Singapore 3rd International Symposium on Flavonoids in Biology & Medicine
November 1989

Liver Protective Activity of IdB 1016 (Siliphos®) A new Flavanolignan Complex

M. Conti, S. Malandrino, M.J. Magistretti*

Inverni della Beffa Research and Development Laboratories, Milan, Italy

No reference on Medline

This substance was tested against its constituents (Silybin and Phosphotidylcholine) for protection against liver poisoning in lab rats. IdB 1016 (Siliphos®) was found to reduce liver cell damage indicators from one poison tested by 43%. For another poison it reduced liver necrosis from 68% in poisoned controls to 5% in treated animals.

The compound was consistently more active than either Silybin or Phosphatidylcholine alone. These results may be explained by the improved bioavailablity of IdB 1016 (Siliphos®)