Ref15P16 - Siliphos® counteracts hepatotoxic effects

Biochemical Pharmacology, Vol. 43, No. 10, pp 2111-2115, (1992)

Lipid Peroxidation and Irreversible Damage in the Rat Hepatocyte Model

Protection by The silybin-phosopholipid Complex IdB 1016

Rita Carini, Adriana Comoglio, Emanuele Albano and Giuseppe Poli*

Department of Experimental Medicine and Oncology, University of Turin, CNR Centre of Immunogenetics and Experimental Oncology, Corso Raffaello 30, Torino, Italy

Abstract-IdB 1016 (Siliphos®) is a new silybin-phospholipid complex which is more bioavailable than the flavonoid silybin itself and displays free radical scavenging and antioxidant properties in liver microsomes. IdB 1016 (Siliphos®) at the concentration which completely prevented MDA formation also protected isolated hepatocytes against toxicity. Similar protection was also obtained in hepatocytes prepared in vivo with IdB 1016 (Siliphos®) while rat supplementation with pure silybin was totally inefficient. These results indicate IdB 1016 (Siliphos®) as being a potentially useful protective agent against free radical-mediated toxic liver injury.

Moreover, it was demonstrated here for the first time that IdB 1016 (Siliphos®) can counteract the hepatotoxic effect of several different compounds acting through oxidative mechanisms, indicating the potential usefulness of the compound as a hepatoprotective agent.